Antimigratory Evaluation from Curcumin-Derived Synthetic Compounds PGV-1 and CCA-1.1 on HCC1954 and MDA-MB-231 Cells

Earlier findings reported the anticancer-mediated activities of curcumin-modified compounds Pentagamavunone-1 (PGV-1) and Chemoprevention Curcumin Analog 1.1 (CCA-1.1) with several mechanisms including cell cycle arrest, reactive oxygen species (ROS) production, migration disruption. Our study aims to evaluate antimigratory activity PGV-1 CCA-1.1 on aggressive breast cancer lines (MDA-MB-231 HCC1954 cells) their effect HER2 protein. The trypan blue exclusion method was conducted for antiproliferative effect. or determined by wound healing assay. Using gelatin zymography, we checked secretion level matrix metalloproteinase (MMP). We also evaluated human epidermal growth receptor-2 (HER2) after incubation in cells western blot. Based antiproliferation assay, MDA-MB-231 were sensitive CCA-1.1. MMP-2 only observed while MMP-9 MDA-MB-231. Both significantly suppressed cells. Moreover, inhibited protein levels although it not significant, whereas did affect This strengthens scientific evidence future exploration as candidate chemotherapy multitarget against cancer.Keywords: analog, migration, MMP-9, HER2, cancer.